Enzyme Libraries for Application
in Industrial and Pharmaceutical Biotransformation
IMEnz Bioengineering BV provides access to unique libraries of enzyme variants and conducts the screening of these libraries for the selection of biocatalysts with desired properties.
The first library that has been made available contains more than 350 protease variants. The individual biocatalysts exhibit a large variation with respect to stability, pH optimum, substrate specifcity, metal ion dependence, and absolute activity, both in aqueous and in organic environments. This particular class of proteases has been shown to be applicable for many kinds of bioconversion reactions, as diverse as hydrolysis and synthesis. The stereoselectivity of transformations obtained by biocatalysts makes them extremely powerfull for chiral resolution applications.
IMEnz Bioengineering BV utilizes the library for the selection and identification
of enzymes with desired or novel properties.
To that goal, IMEnz Bioengineering BV offers the following services:
- development of application-oriented screening procedures
- screening of the libraries for specific biotransformations
- identification of biocatalysts involved
- isolation, production and upscaling of identified, interesting variants
- further improvement of selected biocatalysts by means of protein engineering and or directed evolution
- assistance in obtaining exclusive rights to use selected variants
- assistance in search and operation of new libraries
Other libraries of industrial enzymes, including chitinases, esterase,
lipases and sugar-modifying enzymes are or will become available in due
time also.
For more information contact us now:
Dr. Bertus van den Burg
Manager Enzyme Technology
IMEnz Bioengineering BV
tel: (+31) 50 3132025